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©2020 The Authors. Stem Cells published by Wiley Periodicals, Inc. on the part of AlphaMed Press 2020.Alcoholic liver infection (ALD) is caused by long-term consumption of liquor and has become an important personal and health problem. Intestinal fungal flora (mycobiota) play an important role in ALD, therefore we utilized the mycobiota as an entry point to explore the mechanism of activity of Paeonol against ALD. Here, we unearthed that Paeonol is effective again