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Cholesterol (A), Span 60 (, and sonication time (C) were chosen as independent factors, whereas vesicle size (Y1 in nm), entrapment efficiency (Y2 in %), and medication launch (Y3 in %) were chosen because dependent variables. The vesicle dimensions, entrapment efficiency, and medication launch of optimized CIP niosomes (CIP-NSMopt) had been discovered is 180.34 ± 5.13 nm, 78.32 ± 4.49%, and 82.87 ± 4.01% (in 12 h), correspondingly. More CIP-NS
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