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Bigger multicenter researches of efficacy, safety, and cost-effectiveness are expected. Thirty-three 4-amino-1,2,4-triazole derivatives 1-33 were synthesized by responding 4-amino-1,2,4-triazole with a number of benzaldehydes. The synthetic particles were characterized via1H NMR and EI-MS spectroscopic techniques and assessed with their anti-hyperglycemic potential. Substances 1-33 exhibited great to moderate in vitro α-amylase and α-glucosidase inhibitory activities in the number of