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OBJECTIVE The aim To carry out a historical review of the formation and development of medical forensics in the XIX - early XX century in Ukraine, as well as to identify its trends at the present stage. PATIENTS AND METHODS Materials and methods The article is based on the study of archival and published materials, the results of integrating expert judgments, judicial practice and regulatory acts of the Ministry of Health of Ukraine, interviewing investigators and court experts. In the course of the research a system of scientific metho