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The results revealed EA treatment marketed hippocampal neural proliferation in perimenopausal despair rats via activating the Wnt/β-catenin signaling path, indicating that EA may represent an efficacious therapy for perimenopausal depression. V.The membrane-associated progesterone receptor (MAPR) family consists of heme-binding proteins containing a cytochrome b5 (cytb5) domain described as the clear presence of a MAPR-specific interhelical place area (MIHI