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86%). CONCLUSIONS In summary, a series of azide group containing tetrahydrobenzofuran derivatives have been synthesized and were evaluated for their anticancer activity. It was concluded that the derivatives 4a and 4e exhibited promising anticancer activity. Nature of substituent on phenyl ring seems to be the crucial factor affecting the activity in both the compounds. This is an open access article distributed under the terms of the CC0 Public Domain Dedication.INTRODUCTION Endothelin-1 (ET-1) is potent vasoconstrictive peptide and