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It is suggested that the PR-to-F transition is due to the binding of H2O2 to CuB triggering a structural change together with the uptake of H+ at the catalytic center. In the PM-to-F conversion, these two events are complemented with the annihilation of radical by the intrinsic oxidation of the enzyme. Voclosporin, a novel calcineurin inhibitor approved for the treatment of adults with lupus nephritis, improved complete renal response rates in patients with lupus nephritis in a phase 2 trial. This study aimed to evaluate the efficacy an
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