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In addition, probiotic administration considerably improved the impaired spatial memory in HF rats. CONCLUSIONS We conclude that intestinal flora dysbiosis plays a potential role in aggravating the impaired cognition associated with neuroinflammation and that these effects may be attenuated by probiotics. OBJECTIVE To assess the efficacy of prostaglandin F 2 alpha (PGF2α) in hysteroscopic myomectomy of submucous myomas. DESIGN A single-blind, randomized clinical trial study. SETTING A teaching hospital, affiliate of Iran University of Medi