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In this analysis, we discuss recent advances into the utilization of LNPs for cell-specific specific delivery of nucleic acids. We focus mainly on targeting liver hepatocytes and spleen resistant cells as excellent objectives for gene therapy. We also talk about the potential of endothelial cells as an alternate strategy for targeting organs with a continuous endothelium.Small extracellular vesicles (sEVs), including exosomes as typical instance, tend to be cell-derived vesicles co