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948-8.498, 0.001), and increased mortality after five survived years. The two-sided analytical approach revealed CTC subpopulations associated with ovarian cancer progression and may illuminate a potential treatment-related shift in molecular phenotypes. That approach can identify patients who have elevated risk of recurrence and death due to ovarian cancer and who may require risk-adapted treatment strategies. The two-sided analytical approach revealed CTC subpopulations associated with ovarian cancer progression and may illuminate