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Cardiac surgery-associated acute kidney injury (CS-AKI) occurs in up to 40%~60% of paediatric patients and increases postoperative morbidity and mortality. A goal-directed perfusion (GDP) strategy aimed at maintaining indexed oxygen delivery (DO i) above the critical threshold (reported to be 260~300 mL/min/m in adults) during cardiopulmonary bypass (CP, is effective in reducing the incidence of CS-AKI. However, no clear standards of paediatric critical DO i exist. Our prior prospective cohort study exploring the critical DO i threshol