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How Does ADHD Medication Work? Medicines help to reduce ADHD symptoms by increasing levels of the chemicals dopamine and noradrenaline that transmit messages between brain cells. The most frequently prescribed stimulants are methylphenidate Glycine and atomoxetine. Finding the right dosage and medication can require a lot trial and error. Honest, open communication with your doctor is crucial. Stimulants The stimulant medications prescribed to treat ADHD increase levels of dopam