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RT-PCR analysis confirmed enhanced FGG mRNA levels in the lungs of both smokers and COPD patients compared to non-smokers and in CSE-exposed cells compared to control cells. FGG protein levels were elevated in the lungs of COPD patients and smokers compared to non-smokers and in the lungs of CS-exposed mice compared to control mice. FGG may serve as a biomarker for COPD and may play an important role in its pathogenesis. FGG may serve as a biomarker for COPD and may play an important role in its pathogenesis. This study sought to evaluat