https://www.selleckchem.com/
We report the anti-breast cancer stem cell (CSC) properties of a series of Group 10-bis(azadiphosphine) complexes 1 - 3 under exclusively three-dimensional cell culture conditions. The breast CSC mammosphere potency of 1 - 3 is dependent on the Group 10 metal present, increasing in the following order 1 (nickel complex) less then 2 (palladium complex) less then 3 (platinum complex). Notably, 3 reduces the formation and size of mammospheres to a greater extent than salinomycin, an established CSC-active compound, or any reported anti-CSC metal complex tested
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