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To obtain understanding of the practical variety of syncytin-2 genes in primates, we examined the syncytin-2 gene in "" new world "" monkeys (NWMs). We experimentally evaluated the cell fusion ability of syncytin-2 in people, C. jacchus, and tufted capuchins (Sapajus apella). We discovered that the cell fusion ability of S. apella was lower than compared to real human syncytin-2. Chimeric syncytin-2 constructs revealed that the amino acid differences in the outer lining unit of S. apella syncytin-2