https://abatacept0.com/phenyla....lkylammonium-passiva
Here, we show that DNA-PKcs is poly-neddylated at its kinase domain. The neddylation E2-conjugating enzyme UBE2M and E3 ligase HUWE1 (HECT, UBA, and WWE domain containing E3 ubiquitin protein ligase 1) have the effect of the DNA-PKcs neddylation. Additionally, inhibition of HUWE1-dependent DNA-PKcs neddylation impairs DNA-PKcs autophosphorylation at Ser2056. Finally, exhaustion of HUWE1-dependent DNA-PKcs neddylation reduces the
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