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The Global Asthma Network (GAN) builds on the International Study of Asthma and Allergies in Childhood (ISAAC). To compare asthma prevalence time trends in primary and secondary school children in four Mexican centers participating in ISAAC and GAN. GAN is a cross-sectional, multicenter, epidemiological methodology carried out in groups of primary school children aged 6-7 and adolescents aged 13-14 following the ISAAC Phase Three protocol, with additional questions on risk factors and asthma management. Overall, the prevalence of asthma