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Should the time period between validation of the prime quality and initiation of bypass be extended, it may be advisable to reevaluate the prime quality.Little is reported in the literature regarding hereditary spherocytosis (HS) and cardiopulmonary bypass (CP. We present a case of a 19-month-old girl child who was referred for an atrioventricular septal defect (AVSD) and HS. The patient underwent surgical repair, and an exchange transfusion was performed at the initiation of CPB. No significant hemolysis or events attributed to HS