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The Slovenian tertiary centers have actually an insurance policy of surgery of high-grade SILs and life-long close followup. Radiotherapy is reserved for more obvious intraepithelial lesions classified as carcinoma in situ and unpleasant cancer tumors. Such a distinction can facilitate medical choice to use radiotherapy if total surgical removal is certainly not feasible.BACKGROUND Dimethyl fumarate (DMF), a Nrf2 activator authorized for several sclerosis (MS) in 201