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Moreover, exhaustion of hepatic SIRT1 prevented the accumulation of Nrf2 in nucleus as well as the upregulation associated with antioxidant gene expression when you look at the presence of genistein and/or APAP. Concomitantly, the induced mRNA expression of UDP-glucuronosyltransferases (UGTs) by genistein ended up being mostly determined by the SIRT1 expression and activity. Collectively, our outcomes offer the thought that the strong height of SIRT1 expression and task may express a possib