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Lymphangioleiomyomatosis (LAM) is a rare and progressive cystic lung disease with limited therapeutic options. We retrospectively analyzed the effects of a comprehensive 4-week inpatient pulmonary rehabilitation (PR) program in 58 patients with advanced LAM (FEV1 45 ± 34%predicted, 6-min walk distance (6MWD) 338 ± 167 m). Exercise performance (6MWD + 49 ± 50 m; p less then 0.001) and quality of life (SF-36 physical component + 2.4 ± 7.8 points; p = 0.049 and mental component + 5.2 ± 12.1 points; p less then 0.001) increased significa