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In this study, we synthesized pH-sensitive thiamethoxam-3-(2-aminoethylamino) propyl-bimodal mesoporous silica (P/Thi-NN-BMMs) nanoparticles (NPs). We used this bimodal mesoporous silica (BMMs) mesoporous material as a carrier based on the principle of free radical polymerization. The size of the P/Thi-NN-BMMs NPs was about 891.7 ± 4.9 nm, with a zeta potential of about -25.7 ± 2.5 mV. X-ray powder diffraction analysis, N2-sorption measurements and thermogravimetric analysis indicated that thiamethoxam (Thi) was loaded into the pores of