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RECENT FINDINGS While the pathophysiology of type we refractory celiac infection stays confusing, there have been improvements within the understanding of the pathophysiology of type II refractory celiac condition. It has included recognition for the considerable role of interleukin-15 and somatic mutations in JAK1 or STAT3 in the proliferation of aberrant T cells. As a result has led to potential novel treatments targeting these factors, certainly one of th