https://www.selleckchem.com/pr....oducts/dl-buthionine
In vitro data and extensive in vivo rat data demonstrated delivery of the tracer to the CNS, and its successful ligation to its ASO target in the brain. In an NHP study, the slow tracer kinetics did not allow for specific binding to be determined by PET. A CNS-penetrant radioligand for pretargeted imaging was successfully demonstrated in a proof-of-concept study in rats, laying the groundwork for further optimization. A CNS-penetrant radioligand for pretargeted imaging was successfully demonstrated in a proof-of-concep
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