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Other than thiolate and phosphine ligands, alkynyls are also briefly discussed. Several methods of obtaining chiroptically active nanoclusters are introduced, such as enantioseparation by high-performance liquid chromatography and enantioselective synthesis. Future perspectives on chiral NCs are also proposed. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.BACKGROUND Patient and Public Involvement (PPI) in research ensures that publicly funded research reflects the priorities of the people who will be affected by its results. Co-re