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Nonetheless, pigmentless S. marcescens mutants always emerge after prolonged starvation, which can be a means when it comes to germs to adjust to hunger conditions, but it could be a major problem into the manufacturing application of S. marcescens. To identify the molecular systems of loss in prodigiosin production, two mutants were isolated after 16 days of extended incubation of wild-type (WT) S. marcescens 1912768R; one mutant (named 1912768WR) exhibited reduced producti