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07) was associated with decreased OS. CR at first line (HR 0.09, P .001) and consolidation with ASCT (HR 0.08, P=.015) were predictors of increased OS. In the largest cohort of nPTCL from Latin America, patients had poor survival and high rate of chemo-resistance. In our cohort, the addition of etoposide to the CHOP-21 backbone showed no survival benefit and was associated with high-toxicity and frequent treatment interruptions. Normal LDH values, obtaintion of CR and consolidation with ASCT were independent factors associated with b