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appropriate collaboration will allow researchers to address major biological questions that are more than the sum of the parts. This article is protected by copyright. All rights reserved.OBJECTIVE To describe the use of manual therapeutic plasma exchange (TPE) to manage hepatic encephalopathy (HE) in a dog. CASE SUMMARY A 9-year-old neutered female Dachshund presented for HE secondary to a previously diagnosed portosystemic shunt. The hyperammonemia and severe clinical signs of HE persisted despite extensive medical management. Therapeu
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