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Objectives To test the effectiveness of a simple yet effective therapeutic protocol for the total mouth antimicrobial photodynamic treatment (aPDT) mediated by 450 nm blue LED connected with curcumin in people who have AIDS.Methods Patients were chosen by exclusion criteria and arbitrarily distributed in groups to try the potency of antimicrobial aPDT with curcumin 0.75 mg/mL from the blue LED (67 mW/cm2, 20.1 J/cm2). Before and after the remedies, samples were colle