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Of 63 patients on dabrafenib/trametinib combination, seven had been clinically determined to have a SLR. Each of them had particular cutaneous involvement, plus one also displayed mediastinal and salivary glands involvement. None required systemic corticosteroids or dabrafenib/trametinib discontinuation. Three of these (43%) reached melanoma full remission and so are nonetheless on targeted therapy; and four customers progressed and passed away. A literature review yielded 22 extra si