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No serious complications relevant to the procedure were reported. US-TPVB could be a useful technique for sympathetic blockade in patients with upper extremity pain. US-TPVB could be a useful technique for sympathetic blockade in patients with upper extremity pain. Evidence for efficacy and safety lacks for long-term opioid therapy in patients with chronic non-cancer pain and adverse effects, including affection of cognitive function and quality of life, is of concern. We aimed to investigate cognitive function and health-related quality