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To evaluate the relationship between the frequency of ED visits and outpatient department (OPD) follow-up in sickle cell disease (SCD) pediatric patients. A retrospective cohort study included 247 SCD pediatric patients between January 2016 and December 2018 at the Maternity and ChildrenHospital, Department of Pediatrics, Al Medinah Al Munawarah, Saudi Arabia. Data were extracted from electronic medical record system; patientdemographics, medications, frequency of emergency department (ED) and OPD visits. Pearson correlation coefficient, linear regression a