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Compared with the control group, the lower and higher NLR levels in the NEC group were statistically different. Following univariate analysis, NLR was a risk factor for NEC (odds ratio [OR], 1.40; 95% confidence interval [CI], 1.00-1.90; P = 0.042), and according to multivariate analysis, risk factors for NEC were NLR ≥ 3.20 and NLR 1.60, within 1week before NEC diagnosis. Thus, NLR values of ≥ 1.60 and 3.20 were determined as the predictive cut-off values for protecting preterm infants from NEC (Model I OR, 0.20; 95% CI, 0.10-