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Eventually, we summarized the potential biomedical programs of ROS-responsive nanocarriers in these oxidative stress conditions. We provide ideas that can help in the designing of new ROS-responsive nanocarriers for assorted applications.Macrophages tend to be potent to modulate swelling via phenotypic switch and production of inflammatory elements. Baicalein (BCL) is frequently utilized to ease irritation; but, its application is definitely hindered because of low solubility. Herein, BCL nanocrystals (BNR