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H2AFY is a potential target for liver cancer therapy.Abbreviations APLF aprataxin pnk-like factor; HCC Hepatocellular carcinoma; H2AFY H2A histone family member Y.People with Down syndrome (DS) have increased risk of Alzheimer disease (AD), presumably conferred through genetic predispositions arising from trisomy 21. These predispositions necessarily include triplication of the amyloid precursor protein (APP), but also other Ch21 genes that confer risk directly or through interactions with genes on other chromosomes. We discuss evidence
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