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RESULTS Nine criterion-meeting studies included 244 CRS customers, with diverse outcomes. Eight researches used 16s-ribosomal RNA (16s-rRNA) gene sequencing to assess the sinonasal microbiome and 1 used 16s-rRNA PhyloChip analysis. Seven scientific studies utilized Sino-Nasal Outcome Test scores, 1 applied another CRS symptom metric, and 1 made use of dependence on extra procedures/antibiotics while the major clinical outcome. Three studies claim that baseline variety of phylum Actinobacteria