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Our findings provide evidence for impaired LTD-like plasticity in patients with depression which may be an important mechanism linked to the pathophysiology and treatment of this disorder. Respiratorytract infections (RTIs) and interstitial lung disease (ILD) secondary to interleukin (IL) 12/23 or IL-23 antagonists have been reported in autoimmune diseases. To assess the risk of RTIs and noninfectious ILD with these drugs. We conducted a systematic review and meta-analysis of randomized controlled trials. Risk of RTIs and noninfectious IL