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08, p = .22). Only 23/249 (9%) individual tests had a BD response in FEV of ≥12% and 200 ml. BD response was not related to age or severity of lung disease and led to an immediate change in clinical management in only four cases. Significant BD response in CF patients treated for PEx is rare, shows poor correlation with baseline pulmonary function and does not correlate with the recovery of FEV with treatment. These data suggest that routine testing for BD response is not indicated during PEx. Significant BD response in CF patients trea