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BMI-related SNPs were causally associated with HIC (N = 2772, N = 2259, p 0.001) but not waist circumference-SNPs (N = 2751, N = 228. Genetically determined insulin sensitivity was not causally related to HIC (N = 2752, N = 2286). C-reactive protein and HDL were causally associated with HIC, with higher C-reactive protein and lower HDL leading to higher HIC (N = 2660, N = 2240; N = 2694, N = 2275). This Mendelian Randomization analysis does not support a causal link between hepatic steatosis and HIC. Other components of
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