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This model system may facilitate the research and development of novel treatments for CF-associated gastrointestinal diseases.Chagas disease remains a major social and public health problem in Latin America. Benznidazole (BZN) is the main drug with activity against Trypanosoma cruzi. Due to the high number of adverse drug reactions (ADRs), BZN is underprescribed. The goal of this study was to evaluate the genetic and transcriptional basis of BZN adverse reactions. A prospective cohort with 102 Chagas disease patients who underwent BZN