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Triptolide, extracted from Chinese medicinal materials Tripterygium wilfordii Hook F (TwHF), has immunosuppressive, anti-inflammatory and anti-tumour effects. The purpose of this study was to examine whether triptolide has the neuroprotective effect on cerebral ischemia-reperfusion (I/R) injury and to explore its possible mechanism. The rat model of focal cerebral I/R was established by the suture-occluded method. The SD rats were randomly divided into five groups sham operation group (Sham group), ischemia-reperfusion model group (I/R g