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Whole-cell voltage-clamp tracks in CA1 PC in ex vivo hippocampal slices from AβO-injected mice disclosed that optogenetic activation of SST and PV interneurons improved spontaneous inhibitory postsynaptic currents (IPSCs) selectively at theta and gamma frequencies, correspondingly. Also, analyses regarding the stimulus-response curve, paired-pulse ratio, and temporary plasticity of SST and PV interneuron-evoked IPSCs ex vivo indicated that AβO