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Targeted nanoscale-contrast representatives with enhanced capacity to accumulate in tumors may result in prolonged signal enhancement and improved detection of PCa with ultrasound. Right here we report nanobubbles (N that specifically targets prostate specific membrane layer antigen (PSMA) overexpressed in PCa. The PSMA-targeted-NB (PSMA-N were useful to simultaneously image dual-flank PCa (PSMA-positive PC3pip and PSMA-negative PC3flu) to look at whether the biomarker may be effectively