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Subgroup analysis showed that in the lower Lp-PLA group, Lp(a) level was not associated with functional outcomes, but in the higher Lp-PLA group, Lp(a) level was significantly associated with functional outcomes. After grouped by different levels of Lp(a) and Lp-PLA , the Lp(a) high/ Lp-PLA high group showed the highest incidence of unfavorable functional outcomes at 3months and 1year. Elevated Lp(a) level is associated with unfavorable functional outcomes in patients with ischemic stroke. The increment in both Lp(a) and Lp-PLA are asso