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This analysis is designed to provide a comparative view among SARS-CoV, MERS-CoV while the newly epidemic SARS-CoV-2, in the desire to get a far better understanding of the host-pathogen interaction, host immune responses, and also the pathogen resistant evasion strategies. This predictive view might help in creating an immune intervention or preventive vaccine for COVID-19 in the future.We report that phosphorane can activate (salen)TiCl2 complex to obtai