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But, DNA methylation after cerebral ischemia is not fully understood however. The purpose of this current study was to investigate the interactions between DNA methylation and neuronal cell death after cerebral ischemia. We examined DNA methylation beneath the ischemic problem by making use of transient middle cerebral artery occlusion and reperfusion (MCAO/R) design rats and N-methyl-D-aspartate (NMDA)-treated cortical neurons in major culture. In this study, we demonstrated that DNA methylation enhan