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Right here we report connecting part stores of amino acids X and Z to form 24 cyclic tetrapeptides, cyclo-[XAAZ]-NH2, and stabilise 14-18 membered rings that mimic different kinds of non-regular secondary structures present in necessary protein hotspots. 2D NMR spectra permitted determination of 3D structures for 14 cyclic tetrapeptides in liquid. Five shaped two (i, i + 3) hydrogen bonds and a beta/gamma (6, 7) or beta (9, 19, 2 turn; eight created one (i, i +