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Nevertheless, tamoxifen opposition developed during cancer tumors treatment stays an important challenge. Tongue cancer resistance‑related protein1 (TCRP1), that will be named a novel medication target, is regarding chemo‑resistance in peoples cancers, additionally, it is often overexpressed in various disease cells, such as for example in lung cancer tumors, cancer of the breast, and tongue cancer tumors. However, the effects of TCRP1 on tamoxifen‑resistant breast