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Right here, pharmacokinetics of T-13 and T-26 were examined after intravenous injection (5 mg/kg) and oral administration (60 mg/kg) in male Sprague-Dawley (S.D.) rats, respectively. Plasma concentrations had been characterized utilizing fluid chromatography-tandem mass spectrometry (LC-MS/MS). The oral bioavailability of T-13 and T-26 had been determined to be 10.71% and 65.79%, respectively. Substances T-13 and T-26 were both bad substrates of P-glycoprotein (P-gp), as well as had a much higher bioavailability than pacl
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