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The bicistronic dual-reporter assay and polysome profile revealed that RPLp2 is really important for translating the viral mRNA of PEDV. RNA binding protein and immunoprecipitation assay indicated that RPLp2 interacted with PEDV 5'UTR via association with eIF4E. Additionally, the cap pull-down assay indicated that the viral nucleocapsid protein is recruited in m7GTP-precipitated complexes aided by the support of RPLp2. The heterogeneous ribosomes, which are various in structure, regulate the discerning interpretatio
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